I thought I would do a quick update for everyone and also document my journey on this trial drug from now on. This is something I should have been doing since day one. Better Late Than Never... Lately i have been fatigued and a bit depressed. I'm assuming this is part of the fatigue side effect of the trial drug. So far this medicine has improved my overall quality of life and is keeping the tumor growth at bay. The gamble i made a year ago paid off. The only thing I am worried about so far is the vision issues. I did not have the best vision before I started this drug, but it's a bit worse after starting it. The docs are saying it's muscle fatigue of the eye which is causing my astigmatism to be worse. I do notice vision issues are worse when I am tired and driving at night as well. Traveling every 3 months since January of last year has been draining, but in the long run it is helping me, and hopefully it will bring us closer to a medication that will control VHL...